Arginine is a semi-essential amino acid. L-arginine is converted in the body into a chemical named nitric oxide. Nitric oxide (NO) is a strong neurotransmitter that helps blood vessels relax and develops circulation. Arginine are increasingly being recommended in urology to support the therapy of erectile problems of a mild or medium severity.
L-arginine Erectile Dysfunction Treatment
L-arginine is the precursor of nitric oxide, which is a substance that helps dilate blood vessels and improves circulation. A dose of 5 g per day might be effectual in treating male erectile dysfunction because the erectile process requires nitric oxide synthesized by arginine. Researches have shown that L-arginine may help treat erectile dysfunction in men with low nitrate levels in their blood.
In a study, 2 groups of rats were given free access to arginine which was dissolved in their drinking water. Serum and penile tissue levels of arginine in the treated rats were increased by 64 – 148 percent compared to control animals. A 1999 study reported in the online journal BJU International found that high doses of arginine can help improve sexual function. In a study, men with erectile dysfunction were given 2800 mg of arginine per day for 2 weeks. Six of the fifteen men in the study were helped, though none improved while taking placebo. In another study men with erectile dysfunction were given 1670 mg of arginine per day or a matching placebo for 6 weeks. Arginine supplement was found to be especially efficacious at improving erectile dysfunction in men with abnormal nitric oxide metabolism.
L-arginine used in combination with proanthocyanidins or yohimbine, has been used as a therapy for erectile dysfunction. In clinical trials, an on-demand oral preparation of an yohimbine/arginine combination significantly improved erectile function in men with mild-to-moderate disease whereas neither arginine alone nor yohimbine alone was significantly better than placebo. In a study of 45 men found that one-time use of this combination treatment (3.25 g of arginine plus 6 mg of yohimbine) an hour or two prior to intercourse improved erectile function, particularly in those with just moderate erectile dysfunction scores. Combination therapy was considered successful by 40% of the subjects, compared with 28 % with yohimbine alone and 17 % with placebo.
L-arginine and Pycnogenol
Five clinical trials have found that arginine aspartate and pycnogenol work together to restore sexual function, enable erections, performance, boost libido,and sperm motility, viability, and quantity. Study by researchers at Seminological Laboratory, and reported in the May issue of Journal of Sex and Marital Therapy in 2003 discovered that administration of Pycnogenol and L-arginine important enhances sexual function in men with erectile dysfunction. During the three-month study period participants received 3 ampoules Sargenor a day, a drinkable solution of the dipeptide arginyl aspartate. (equivalent to 1.7 g L-arginine). Throughout the second month, participants were additionally supplemented with 40 mg Pycnogenol 2 times per day; during the third month, the daily dosage was increased to 3 time 40 mg Pycnogenol. After one month of therapy with arginine, a statistically non significant number of 2 participant (5%) experienced a normal erection. Therapy with a combination of Pycnogenol and L-arginine for the subsequent month increased the number of men with restored sexual function to 80%. After the third month of treatment, 92.5% of the men experienced a successful erection. In another study, investigated 50 middle-aged men with mild to moderate erectile dysfunction who were treated for one month with placebo or with arginine aspartate and pycnogenol. Therapy with arginine aspartate and pycnogenol for one month restored erectile function to normal, and intercourse frequency doubled.