Guanabana Anticancer Effects and Research Findings

Guanabana (Annona muricata), also known as soursop and graviola, is a tropical evergreen tree. The  fruit and the leaves of  the guanabana tree are used in traditional medicine. Guanabana possesses unique  phytochemicals known as Annonaceous acetogenins, which showed antitumor activities.

Guanabana Cancer Benefits and Experiments

Guanabana (graviola) contains chemicals called annonaceous acetogenins, which are thought to be the  active component. Annonaceous acetogenins are, powerful antioxidants that have been found to help avoid and treat illness. In lab experiments, guanabana selectively hunts down and kills 12 different types of  cancer cells including colon, breast, prostate, pancreatic, and lung cancer. However there haven’t been  any large scale studies in humans.

In 1997, researches at “Purdue University” proved that annonaceous acetogenins appeared especially  effective at destroying cellsGuanabana that had survived chemotherapy. A study conducted at “Purdue University”,  showed that the acetogenins can selectively inhibit the growth of cancer cells and furthermore inhibit  the growth of tumor cells resistant to doxorubicin, respecting the integrity of cells healthy tissue. Many of the annonaceous acetogenins have a cytotoxicity with ED50 values as low as 10-9 ug/ml. In other  study performed by experts at the “Purdue University”, it was demonstrated that the acetogenins of  graviola are very strong to have an ED50  of up to 10 to 9 micrograms per milliliter, resulting to have  about 10,000 times the power of adriamycin.

In a 2002 study performed by Taiwanese scientists and reported in the Journal of  Natural Products, the  guanabana extract showed the ability to kill liver cancer cells. Annonaceous acetogenins (guanabana extract) were influential against the growth of  Adriamycin – resistant human mammary adenocarcinoma by blocking access of cancer cells to ATP and by inhibiting the actions of plasma membrane glycoprotein. A research reported in the July 2011  edition of “Nutrition and Cancer” showed that guanabana extract inhibits EGF receptor production and slows the growth of  human breast cancer cells cultured in test tubes and grafted onto mice. According to a study reported in the Nov 2010 edition of  Molecules, the A. acetogenins in guanabana decreased the proliferation of lung cancer and laryngeal cells in the lab. The recent study, conducted by a research team at the “Department of  Biochemistry and Molecular Biology at the University of  Nebraska Medical Center“, shows that guanabana kills pancreatic cancer cells by inhibiting cellular metabolism.

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