Medical Effects of Cranberry Fruit

Cranberry (Vaccinium macrocarpon) is an evergreen shrub related to buckberry, blueberry, bilberry, and huckleberry. The reddish-black fruit appear in the months of June and July. Fruit contain compounds called proanthocyanidins, which give them their red color.

Cranberry Juice Benefits and Diseases

Cranberry are rich in antioxidants. The important type of polyphenolic compound found in cranberry is proanthocyanidins. Antioxidants are substances that protect cells from oxidative damage caused by molecules called free radicals. Free radicals are unstable molecules that attack normal cells and damage membranes. Cell death caused by free radicals contributes to a variety of diseases, including heart disease, some forms of cancer and nervous system disorders such as Alzheimer’s. Elevated antioxidant amounts in the body may protect against damage to cells and cellular components, thus helping to reduce the risk of many chronic degenerative diseases.

Various polyphenolic compounds such as flavonoids have been identified as having powerful antioxidant activities. Cranberry are one of the most rich sources of  flavonoids that have a potent antioxidant and anti-inflammatory effects. Therefore, consumption of cranberries could be of  importance not only in the maintenance of  health but also in preventing cardiovascular disease. Cranberry score high on the antioxidant scale at 1750 ORAC units per 100 g of fresh fruit. Cranberry have been shown to contain more antioxidant phenols than 19 commonly eaten fruits according to a research reported in the Nov, 2001 issue of  the Journal of Agriculture and Food Chemistry.

Urinary Tract Infections (UTIs)

Cranberries has a long history of use  primarily for treating urinary problems. New researches have shown it can reduce the ability of  Escherichia coli to adhere to the lining of the bladder and urethra, reducing the potential for urinary tract infections. Some lab experiments showed  that cranberry also prevent other microorganism known as Helicobacter pylori from adhering to cell walls.

Previously, scientists believed that the effect of cranberry juice to help prevent urinary tract infections was partly related to the potent acidity of the cranberry. However scientists don’t believe this explanation any more. No longer, researches show that cranberry juice may prevent bacteria from attaching to the walls of the urinary tract. Cranberry juice contain proanthocyanidins, which inhibit the fimbrial adhesion of bacteria, including E. coli, to the urinary tract epithelium and hence the subsequent reproduction required for infection. The proanthocyanidins in cranberry inhibit the adherence of  Escherichia coli fimbriae to uroepithelial cells in vitro. Adhesion of  Escherichia coli bacteria  to cells lining the urinary tract is the first step in the development of a urinary tract infections, and Escherichia coli is the cause of approximately 85 % of urinary tract infections.

Research shows that drinking cranberry juice can help prevent repeated urinary tract infections in older women. In one study of older women, cranberry juice decreased the amount of bacteria in the bladder compared to placebo. Other a study demonstrated that younger women with a history of  frequent urinary tract infections (UTIs) who took cranberry capsules had fewer UTIs compared to those who took placebo. A study reported in the Phytomedicine concluded that cranberry extract proved effective in preventing recurrent UTIs.

Benign Prostatic Hyperplasia and Chronic Prostatitis

Cranberry JuiceCranberry extract appears to be a  effective therapy to manage symptoms of  Benign prostatic hyperplasia (BPH) and chronic prostatitis. A 2011 study performed at the “Catholic University of  Korea College of Medicine “, demonstrated that cranberry extract reduced bacterial growth in the prostate tissue of animals with chronic bacterial prostatitis. During the 6-month a study, participants were given 1,500 mg of cranberry fruit powder per day. Compared with the control group, patients symptoms in the cranberry group significantly healed in a few areas by the end of the study, including quality of  life, rate and amount of urinary frequency, urine flow, urgency, and waking at night to urinate. In a study “Cancer Management and Research” reported that cranberry extract was effective in reducing the risk of urinary tract infections and lower urinary tract symptoms in men who were undergoing radiation treatment for prostate cancer. Particularly, of the 184 patient given cranberry extract, just 16 experienced a urinary tract infection associated with radiation treatment, compared with 45 of 186 men in the control group.

Peptic Ulcers

Some preliminary research findings demonstrate that cranberries may be useful in the prevention of peptic ulcers through the inhibition of  Helicobacter pylori adhesion to gastric mucus and stomach epithelium. Regular consumption of cranberry juice can suppress Helicobacter pylori infection, a important factor in peptic ulcer disease and gastric cancer. In the study which was reported in the Apr 2005 edition of  the journal Helicobacter, researchers proved that the usage of 250 ml of cranberry juice twice daily for 90 days suppressed H. pylori infection compared with a placebo.

Anticarcinogenic Activities

In 1996 lab experiments performed by University of  Illinois researchers and reported in “Planta Medica” showed the possible anticarcinogenic activities of cranberry. In studies of cancer prevention and cure, cranberries extracts showed  anti-proliferative activity against breast, prostate, colon, liver and oral cancer cell lines in vitro. In a study performed by scientists at the Department of  Physiology & Pharmacology, University of  Western Ontario, investigated the effect of cranberry extract on mice that had been injected with human breast tumor cells, prostate cancer cells and colon cancer cells. As a result, in all cases decrease the growth and metastasis of the cancer tumors.

Cardiovascular Disease

Cranberries may  help to protect against cardiovascular disease. Cranberries contain important levels of  flavonoids compounds that have been showed to inhibit low density lipoprotein oxidation. Flavonoids have been shown to function as strong antioxidants both in vitro and in vivo and may lessen the risk of atherosclerosis (hardening and narrowing of the arteries). Atherosclerosis can slowly narrow and harden the arteries throughout the body. This condition causes cardiovascular disease that lead to heart attacks and stroke.

Cranberries are especially important  source of phenolic phytochemicals, including phenolic acids and flavonoids. The cranberries flavonoids belong to 3 groups; anthocyanins, flavonols, and proanthocyanidins. Polyphenols and flavonoids improve the function of  platelets, irregularly shaped cells in the blood that help with clotting. Latest research findings demonstrate that polyphenols, including those found in cranberry, may contribute to reducing the risk of cardiovascular disease by increasing the resistance of  LDL to oxidation, inhibiting platelet aggregation, reducing blood pressure.

Dosage

The National Kidney Foundation suggests drinking 300 ml glass of cranberry juice cocktail a day may help prevent urinary tract infections. If you prefer in capsule form, the University of  Maryland Medical Center (UMM) suggests 300 to 400 mg daily in divided doses. For BPH; some researches shows that taking dried cranberry capsules, 3 times daily for 6 months, might improve urinary symptoms and lower blood levels of PSA.

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