Methylcobalamin is the special form of vitamin B12 needed for nervous system. Is used at primarily in your liver, brain and nervous system. Methyl B12 is the just active form of B-12 in the brain outside the mitochondria. The liver converts a little amount of cyanocobalamin into methylcobalamin within the body, however high levels of methylcobalamin are needed to correct neurological defects and protect against aging. The liver converts approximately 1 percent of ingested cyanocobalamin into methylcobalamin. Symptoms of a lack of vitamin B12 in the nervous system might include numbness, tingling, loss of feeling sensation, nerve pain, muscle cramps and slowness of reflexes.
Methylcobalamin Injection Benefits
Methyl B12 is necessary for the health of nervous, immune, and circulatory systems. One of the main ways that methylcobalamin works, is through the detoxification of toxic substances in the body. Methylation is the one of the basic processes through which the body detoxifies.
Pernicious anemia is a chronic disease caused by impaired absorption of vit B12 because of a lack of intrinsic factor in gastric secretions. Vitamin B12 is critical for the manufacture of new red blood cells. Patients who have pernicious anemia can’t absorb enough B12 from nutrient. Ordinarily a protein called intrinsic factor, which is made in the stomach, attaches to vitamin B12 and carries through the intestinal wall into the blood stream. When the stomach does not make enough intrinsic factor, the intestine cannot properly absorb B12. In other words A lack of intrinsic factor leads to vitamin B12 deficiency. Methylcobalamin is more effective than traditional forms of vitamin B12 for treating pernicious anemia.
Homocysteine is a naturally synthesized by-product of methionine metabolism. Elevated levels of homocysteine are associated with a reduce in cognitive function and brain vascular complications. Researches shows that high levels of homocysteine may important enhance the risk of heart disease and stroke. Methylcobalamin may perform its neuroprotective activity through increased methylation, acceleration of nerve cell growth or its capability to promote wholesome homocysteine rates. Methyl B12 acts as a cofactor in the conversion of homocysteine to methionine. Methylcobalamin and 5-methyltetrahydrofolate are very important to the elimination of homocysteine. When treated with 1000 micrograms of methylcobalamin daily for 3 weeks, homocysteine levels decreased significantly.
Methyl B12 may help to moderate levels of glutamate in the brain, encouraging wholesome brain cell activity, mood, memory and cognitive function. It is the methylcobalamin form of vit B12 that has been used in most Japanese and European studies showing efficacy against neurological problems. Methyl B12 is many important in the avoiding of neurological disorders, as it prevents nerve damage by maintaining myelin, the fatty sheaths that cover and protect nerve endings. Wholesome myelin sheaths provide electrical insulation around the nerve tissues and speed up electronic impulses essential to appropriate functioning and message delivery of stimuli though the nervous system. Some researches indicates that methylcobalamin shows better transport to organelles within nerve cells than does cyanocobalamin.
Methyl B12 contributes to the formation of lipids and proteins, the synthesis of DNA and RNA for cell reproduction, and the strong of the immune system. A study published in the “Journal of Clinical Immunology”; methylcobalamin showed important T cell-enhancing effects when the T cells were exposed to certain antigens. Researches showed that methylcobalamin supplement in people with insufficient vitamin B12 levels developed CD4/CD8 ratio and naural killer cell activity, and augmented CD3-CD16+ cells, suggesting an important role in cellular immunity. Animal-based studies have showed that methyl B12 and adenosylcobalamin increase survival time and decrease tumor growth in some forms of cancer. In addition methylcobalamin has been shown to increase the effectiveness of methotrexate, a medication used in the therapy of cancer.
Neuropathy means damage of nerve fibres in patients with diabetes. Individuals with diabetes usually have neuropathy of the feet. Methylcobalamin, may prove useful to those suffering from pain and numbness associated with neuropathy. Ultra-high doses of methylcobalamin were found to promote nerve regeneration in a experiment performed by the “Department of Neurology” in Japan.