Magnesium ions regulate over 300 biochemical reactions in the body through their function as enzyme cofactors. Helps maintain healthy muscle and nerve function, keeps heart rhythm steady, supports a normal immune system, and keeps bones potent. Also, plays an momentous role in the central nervous system, regulating neurotransmitter metabolism and modulating the sensitivity of nerve receptors, including those related in the “fight or flight” stress response. A deficiency of magnesium can present common psychiatric symptoms including anxiety, depression, restlessness and irritability. Experts estimate that the average person’s body contains about 25 gr of magnesium, and about half of that is in the bones. Only 1 percent of magnesium in the body is essentially found in blood, and just 3 percent is found in blood serum. Hypomagnesemia (magnesium deficiency) is defined as having magnesium levels that are less than 1.8 mg/dL.
Magnesium and Anxiety Problems
Magnesium is a calming mineral that helps avoid anxiety, fear, nervousness, restlessness and irritability. Some studies it was shown that magnesium therapy resulted in faster improvement from major depression including symptoms of headache, anxiety, irritability, insomnia and short-term memory loss. Symptoms of chronic magnesium deficiency include paranoia, anxious behavior, apprehension, depression, confusion, anger, nervousness, insomnia. Magnesium is the first mineral to be depleted when the body is under external or internal stress; it is furthermore the first mineral to help recovery from, stress, anxiety and mineral imbalances.
Magnesium is an inhibitor of the N-methyl-D-aspartate, receptor in the brain. Inhibition of the N-methyl-D-aspartate (NMDA) activity may be associated with anti-anxiety activity, according to a 2004 research reported by Ewa Poleszak. Magnesium ions regulate calcium ion flow in neuronal calcium channels, helping to regulate neuronal nitric oxide production. In MG inability, neuronal requirements for magnesium may not be met, causing neuronal injury which could manifest as depression. Magnesium therapy is hypothesized to be influential in treating major depression resulting from intraneuronal mg deficits. CSF (Cerebral spinal fluid) magnesium has been found low in treatment-resistant suicidal depression and in people that have attempted suicide.
Catecholamines cause general physiological changes that prepare the body for physical activity. Some characteristic effects are increases in heart rate, blood pressure, blood glucose levels, and a reaction of the sympathetic nervous system. The important catecholamines are dopamine, norepinephrine, and epinephrine. Catecholamines activate an area inside the brain named the amygdala , which appears to trigger an emotional response to a stressful event. When there is a perceived danger or stress, the brain releases these hormones, which by leaps and bounds speed up the heart rate, increase the blood pressure, and put the body in a state of readiness for physical action. Also, during the stressful condition catecholamines suppress activity in areas at the front of the brain concerned with short-term memory, concentration, inhibition, and rational thought. Increased catecholamines lead to excretion of magnesium in urine, which reduces the concentration of magnesium in the body. Catecholamine secretion is suppressed in the presence of sufficient magnesium levels.
“Brain Derived Neurotrophic Factor” (BDNF) is produced inside brain neurons or nerve cells, especially in learning centres. The experts found that elevated brain magnesium was able to induce the production of “Brain Derived Neurotrophic Factor“, your brains rejuvenation compound. Scientists from the “School of Medicine at the University of Texas” in Austin found that elevating brain levels of magnesium can help undo the bad programming from prior stress experiences by helping to create new brain response patterns not influenced by anxiety or fear. Experts included supplementary magnesium to a group of volunteers and found that elevated brain magnesium was able to induce the production of BDNF, a compound used by the brain to rejuvenate cellular function. This led to an increase in synaptic plasticity, enabling the learned fear response to essentially change.
In an 1992 study reported in Ceskoslovenská Psychiatrie, 20 women with anxiety revealed that a combination of anxiety medicines and magnesium led to a more quick recuperation of anxiety when compared to standard therapy alone. A study in France of 264 people with generalized anxiety disorder found that a statistically significant number of women and men reported developments on a magnesium treatment. An epidemiological study found correlate between low magnesium levels and symptoms of depression in Norway. In a 2008 clinical trial showed that magnesium was as effectual as the tricyclic antidepressant imipramine in treating depression in diabetics and without any of the negative effects of imipramine (Magnesium Research 2008-December). A study reported in the October 2010 edition of “Psychology and Behaviour” showed that low magnesium levels in blood serum and brain were amply related with behavior symptoms associated to anxiety.
Magnesium Anxiety Dosage
General magnesium dosage for adults involves 270 mg to 400 mg per day for men and 280 mg to 300 mg per day for women. A study described by “National Institutes of Health” demonstrated a reduce in symptoms of anxiety and depression in people who took 125 mg to 300 mg of magnesium, as taurinate and glycinate, daily with each meal and at bedtime. Vit B6 in the helps determine how much magnesium absorbs into cells. High doses of zinc in interfere with the absorption of magnesium.