Ubiquinol is the reduced, active antioxidant form of CoQ10 (Coenzyme Q10). Researches show supplement with Ubiquinol to be up to eight times more effective at increasing the concentration of ubiquinol in your blood plasma. CoQ10 highest levels are found in the heart, liver, kidneys, and pancreas. The level of CoQ10 in tissues decreases as people get older.In 1977 the “Journal of Orthomolecular Medicine” reported that a 77 year old person has 57 % less Coenzyme Q10 than a 20 year old.
Coenzyme Q10 is produced primarily in the liver and then converted to ubiquinol in the body through an enzymatic process known as the redox cycle which is short for reduction oxidation. More than 90 percent of the circulating Coenzyme Q10 in our body is present as Ubiquinol. Coenzyme Q10 levels within the body usually begin decreasing as early as age 20, suggesting that it has a close connection with aging. Without adequate levels of these critical substances, the body produces less energy and lacks a powerful defense against oxidative stress. It may be possible to achieve the sustained high blood levels of biologically active ubiquinol Coenzyme Q10 necessary to delay particular manifestations of aging and its related disorders.
Ubiquinol is a powerful antioxidant used to support optimum cardiovascular and nervous system health. Ubiquinol rates have been shown to be suppressed in older people and those with cardiovascular, liver, neurological, and diabetes related diseases. This substance is used usually to avoid or treat cardiovascular diseases such as high blood pressure, congestive heart failure, cardiomyopathy, mitral valve prolapse, and angina.
Ubiquinol is a strong antioxidant that helps protect our body from free radical damage. A essential role for ubiquinol is to inhibit lipid peroxidation. Coenzyme Q10 is a important component in the production of 95 percent of cellular energy in the body. Ubiquinol has been shown to be an substantial fat-soluble antioxidant with the capability to protect and regenerate Vitamin E in cell membranes.
Ubiquinol is the antioxidant form of Coenzyme Q10 and is necessary for mitochondrial synthesis of energy. The energy each cell produces is in the form of a molecule named ATP (adenosine triphosphate), which is made in the energy powerhouse of the cell known as the mitochondria. Ubiquinol has been shown to promote ATP production in the mitochondrial inner membrane. A common study between Tsukuba University and Waseda University showed positive effects of ubiquinol on middle-aged and elderly women. Following an 8-week period of supplement with 150 mg ubiquinol per day, participants displayed important improvements in physical activity and mental health scores.
CHF (congestive heart failure) means the heart cannot pump enough blood to keep up with the body’s needs. Patients with heart failure have been found to have lower levels of Coenzyme Q10 in heart muscle cells. In a clinical study of patients with congestive heart failure were given 580 mg per day of ubiquinone. These individuals found increases in blood levels of CoQ10 levels, along with important developments in the ejection fraction of the heart and improvement of the left ventricle, the part of the heart that sends blood out to the body. In other, randomized placebo controlled, double-blind study, 641 people with more severe congestive heart failure were given either a placebo or 150 mg/day of Coenzyme Q10 for one year. The number of patients requiring hospitalization because of worsening failure was 38 percent less in the Coenzyme Q10 group. Ubiquinol were associated with improvements in the capability of the heart to pump blood, as well as general heart health scores, according to results reported in the “American Journal of Clinical Nutrition“.
In one double-blind study, therapy with 150 mg/day of CoQ10 for 4 weeks, the episodes of chest pain was decreased in the treatment group by 53 percent. One clinical trial found that patients who took daily ubiquinol within 3 days of a heart attack were less likely to have subsequent heart attacks and chest pain. Also, some researchs suggest that ubiquinol may help avoid heart damage caused by certain chemotherapy drugs, adriamycin.
A meta-analysis of 12 clinical trials demonstrated systolic blood pressure could reduce up to 17 mm Hg, while diastolic blood pressure could decrease up to 10 mm Hg with Ubiquinol. In a 12-week, double-blind, placebo-controlled study of 74 patient with diabetes, use of Coenzyme Q10 at a dose of 100 mg twice daily important decreased blood pressure as compared to placebo.
Long-term use of statin drugs can increase risk of nerve damage and rhabdomyolysis. That because statins decrease the activity of HMG-CoA reductase, an enzyme that’s involved in both cholesterol and Coenzyme Q10 production. Statin medications have been shown to lower CoQ10 levels by 40 percent, while aging has been shown to reduce Coenzyme Q10levels by 72 percent. Ubiquinol may help limit muscle pain from taking statins and help avoid rhabdomyolysis. A double-blind study found CoQ10 can decrease muscle pain associated with statin medication use. participants were given 100 mg Coenzyme Q10 for 30 days finding pain severity decreased by 40 percent, and pain interference with daily activities decreased by 38 percent in the Coenzyme Q10 group.
According to researchers, the amount of Coenzyme Q10 in the seminal fluid of men has a correlation to their sperm count and sperm motility. Ubiquinol may increase sperm motility in asthenozoospermic men. A study reported in 2012 ” The Journal of Urology” investigated the effects of the ubiquinol in participants with male infertility. A total of 228 men participated in the double-blind, placebo controlled, randomized clinical trial over a 26-week cure period. The study findings showed that supplement with 200 mg of ubiquinol per day important improved sperm density, sperm motility, and sperm strict morphology. In a study conducted at the Polytechnic University of Marche 60 infertile men between the ages of 27 and 39 were given a daily dose of 200 mg of Coenzyme Q10 or placebo for six months, with a three-month follow-up. Coenzyme Q10 increased significantly in seminal plasma and sperm cells after therapy.
Studies show it can reduce the frequency of headaches by approximately 30% and the number of days with headache-related nausea by approximately 45% in adults. 32 patients with migraine were treated with 150 mg of Coenzyme Q10 daily. More than 60 %of the participants experienced a 50 % or greater reduction in the number of days they suffer headaches. After 3 month their migraine frequency fell by an approximate of 55 %.
In 2002, a study was reported which examined the effects of CoQ 10 in people with early Parkinson’s disease. The researchers in that multi-center study found that Coenzyme Q10 reduced the functional decline in Parkinson’s disease. (2002 study in 80 Parkinson’s disease patients found 1200 mg/day reduced the progression by 44 percent)
Sufficient ubiquinol status is essential for the healthy functioning of our immune system. Research findings indicate that ubiquinol is an critical component, likely at the mitochondrial level, for the optimum function of the immune system. Models of the immune system including phagocytic rate, circulating antibody level, neoplasia, viral infections were used to demonstrate that ubiquinol is an immunomodulating agent. In a study of 8 chronically ill patients, administration of 60 mg/day of Coenzyme Q10 was associated with noteworthy increases in serum levels of IgG (immunoglobulin G) after 27-98 days of cure.
For the first 2-3 weeks, 200-300mg per day is a recommended level to replenish body’s ubiquinol levels. Later, a maintenance dose of 100-200mg per day should be enough. Ideal blood levels for those afflicted with congestive heart failure or neurological disorders are considered to be greater than 3.5 micrograms per milliliter. A clinical trial demonstrated that supplementation with only 150 mg per day (within 28 days) of ubiquinol resulted in CoQ10 blood levels of 3.84 mcg/mL. In study participants who took 300 mg per day of ubiquinol, blood CoQ10 levels reached 7.28 mcg/mL.
Some of the doses used in studies;
For reducing the risk of next cardiac problems in individuals with recent myocardial infarction; 120 mg daily in two divided doses. For congestive heart failure; 90 to 200 mg. For angina; 150 mg. For high blood pressure; 120-200 mg per day divided into two doses. For Parkinson’s disease; 1,200 mg. For migraines; 100 to 150 mg. For infertility in men; 200-300 mg per day. For HIV/AIDs; 200 mg. For gums; 30–100 mg.