Xylitol Danger and Effects

Xylitol is a natural substance found in fibrous fruit, and vegetables as well as in corn cobs and various hardwood trees like birch; and is additionally produced naturally in the human body. The body, produces up to 15 g of xylitol each day through normal food digestion processes. This substance was first found in 1891 by a German chemist, Emil Fischer. Xylitol is found in the fibers of many vegetables and fruits, and can be extracted from various berries, oats, and as well as fibrous material such as corn husks and and birch. (Usually is produced in the Finland, United States, and China).  In Finland, Japan and many other countries, xylitol is widely used in candy, gum and oral care products.

Effects

XylitolXylitol is considered a “sugar-free” sweetener. It includes 40% less calories and 75% fewer carbohydrates than refined sugar. Xylitol has been shown in several studies to be very slowly metabolized.  Sugar has a 100 Glycaemic Index and xylitol has just 7. In 1983, a joint expert committee of the Food and Agriculture Organization of the United Nations and World Health Organization the approved that xylitol is a safe sweetener for foods. Also, Food and Drug Administration approved this substance in 1986.

According to Xylitol.org;  sugar feeds bacteria in your mouth, causing them to multiply rapidly. This metabolic process produces acids that cause cavities to begin to form. When you use xylitol gum, the acid attack that would otherwise last for over half an hour is stopped. Because the bacteria in the mouth causing caries are unable to ferment xylitol in their metabolism, their growth is reduced. The number of acid-producing bacteria may fall as much as 90 percent. Bacteria are unable to produce acid in the presence of xylitol and as a sequel the plaque pH does not decrease. In a 1980’s double blind trial 1,277 children chewed gum several times a day. Some were given normal gum sweetened with sucrose; others were given gum with xylitol or sorbitol. After 40 months of gum chewing the xylitol group experience 73 percent less caries, sorbitol group a decrease of 26 percent, and an enhance of 120 percent of caries in the sucrose group.

Researches have shown xylitol chewing gum can help avoid acute otitis media the act of chewing and swallowing assists with the disposal of earwax and clearing the middle ear, while the presence of xylitol avoids the growth of bacteria in the eustachian tubes which connect the nose and ear. According to the findings of 2 double-blind trials, the occurrence of acute otitis media was decreased by 40 percent in children given xylitol chewing gum. A 5 percent concentration of xylitol inhibited the growth of Streptococcus pneumoniae. In an in vitro experiment using a 5% solution of xylitol, scientists showed that the mucosal attachment of Streptococcus pneumoniae and Haemophilus influenzae was decreased by factors of 68% and 50%. Xylitol gum was shown to decrease the incidence of ear infections in children, in a study reported in a 1996 edition of the “British Medical Journal“.

Xylitol Danger

Typical recommended dose of xylitol varies between 6 g and 20 g daily. When consumed in highly dose, cause general discomfort in the abdomen. The significant side effects reported from oral xylitol use at a dosage exceeding 40 to 50 g/day included nausea, bloating, colic, and diarrhea. It should be noted also; some xylitol products include substances, fillers or various sweeteners that are not natural. These are not recommended for those seeking the effects of an all-natural product like xylitol. Xylitol is occasionally applied in intravenous infusions for patients in the in surgical patients. But, xylitol intravenous infusions have led to noteworthy increases in uric acid, bilirubin, lactic acid, and alkaline phosphatase levels. According to a report published in 2001 in the Deutsche Medizinische Wochenschrift, use of xylitol in IV administered drip may have caused renal oxalosis.

There is serious xylitol risk for pets. Particularly, xylitol toxicity in dogs can be acute. In dogs, xylitol is a powerful promoter of insulin release, and can cause serious hypoglycemia, with ataxia, and seizures.  Within 30 minutes of consuming a little amount of a product sweetened with xylitol, dogs experience rapidly plummeting blood sugar, vomiting, and can experience difficulty in standing. A dog suffered hypoglycemia, vomiting and fulminant liver failure after ingesting half of bread containing xylitol. In another incident, 8 dog were examined for treatment of vomiting, hyperglycemia, lethargy, ecchymotic, thrombocytopenia and hyperbirubinemia.

Mulberry Benefits and Medical Effects

Mulberry (Moraceae family) is a deciduous, fruit-bearing tree. There are ten  type of mulberry tree. The usually well-known being black mulberry and white mulberry. Mulberry is rich in polyphenols, flavonoids, alkaloids, and anthocyanins, which have been suggested to be responsible for medical effects. In addition, one of the original property of the mulberry leaf is that it includes compounds that inhibit intestinal enzymes from passing sugars into the bloodstream. The Chinese Pharmacopoeia lists the fruit, leaves, and root bark as ingredients in pharmacological preparations.

Mulberry Benefits

Mulberry, are very rich in iron, for maintaining a healthful count of red blood cells and preventing anaemia. In Traditional Chinese Medicine this fruit are considered a blood tonic. Iron deficiency anaemia occurs when there isn’t sufficient iron in the body. The important symptoms of iron deficiency anaemia are tiredness, lethargy and shortness of breath.

Japanese scientists discovered that mulberry leaves include substance that inhibit intestinal enzymes from passing sugars into the bloodstream. A compound in mulberry leaves 1-deoxynojirimycin (DNJ), avoids diabetes according to scientists at the “Japan International Research Center for Agricultural Sciences“. This inhibitor compound can just be extracted from the mulberry leaf. In a study, taking 1 gram of the powdered leaf (white mulberry) 3 times a day for four weeks reduced fasting blood sugar levels by 27 percent, compared with an 8 percent reduce with the diabetes drug glyburide, 5 mg daily.

MulberryMulberries include anthocyanins, a strong type of antioxidant. As an antioxidant, anthocyanins help rid the body of the free radicals that cause oxidative damage in the body. In the lab, have been found to inhibit some human tumor cells. In a study showed that anthocyanins effectively halted colon cancer cell growth, killing 20 percent of the malignant cells without damaging non-cancerous cells. Mulberry anthocyanins, cyanidin 3-glucoside and cyanidin 3-rutinoside, exhibited an inhibitory activity on the migration and invasion of a human lung cancer cell line. Anthocyanins have demonstrated anti-oxidative and anti-inflammatory  properties, and a high intake of anthocyanin have indicated positive effects on blood pressure and other cardiovascular risk factors. Mulberry includes cyanidin 3-glucoside (an anthocyanin), which epidemiological studies verify decreases the risk of degenerative ailments such as chronic arthritis and atherosclerosis. According to a study reported in the 2006 of the Journal of Medicinal Food, mulberry fruit extract provided anti-inflammatory activity for arthritic rats.

Mulberries include resveratrol. Resveratrol also, an important antioxidant found in black grapes and red wine. Free radicals are unstable molecules that attack normal cells and damage membranes. As an antioxidant, resveratrol fights these free radicals to keep the cells and tissues normal and free from damage. The antioxidant effect of resveratrol helps to avoid damage to DNA, influences the transcriptions of genes responsible for redox metabolism and inhibits proliferartion of cancer cells. Resveratrol has  been found to increase expression and activation of one substantial “suicide” pathway known as p53. Resveratrol dilates blood vessels to develop blood flow and increases nitric oxide production, which is a important Resveratrol part of healthful blood flow and heart health. A study, reported in the journal “Biofactors” in September 2010, found that resveratrol triggers the release of nitric oxide, which plays an significant role in relaxation of blood vessels. Resveratrol helps reduce inflammation and makes it more difficult for platelets to stick together and form the clots that can lead to a heart attack. In a January 2012 placebo-controlled study of forty patients who had suffered a heart attack, scientists at the “University of Pecs“, found that taking 10 mg of resveratrol daily for 3 months boosted endothelial function.

According to a study published in 2007 in the “Neuroreport“, mulberry leaf extract may play a role in preventing neurodegenerative ailments. Antioxidant effectiveness present in white mulberry leaves is gamma-aminobutyric acid (GABA) enriched, which may provide a neuroprotective feature against cerebral ischemia as well as neurotoxins. Neurological diseases known as Parkinson disease are associated with GABA reason to depletion in brain.

Raspberry Benefits and Ellagic Acid

Raspberry, (Rubus idaeus) is the fruit of a wide variety of species of the genus Rubus. They may be black, purple, red, or yellow-fruited types. Raspberries have high amounts of phenolic flavonoid phytochemicals such as ellagic acid, anthocyanins, cyanidins, quercetin, gallic acid, pelargonidins, kaempferol and salicylic acid. According to researches, phytonutrients such as ellagic acid, anthocyanins, quercetin, cyanidins, gallic acid, salicylic acid and kaempferol provide prevention against inflammation, cancer, and neurological illness. New researches has shown that the ellagic acid in raspberries is highly bio-available.

Raspberry Benefits

In lab experiments, ellagic acid seems to decrease the activity of estrogen in promoting growth of breast cancer cells in tissue cultures. A research in cell cultures found that ellagic acid may act against substances that help tumors to form new blood vessels. Ellagic acid causes apoptosis of human cervical cancer cells, induces G1 inhibition of cancer cell division, and avoids destruction of the P53 gene by cancer cells. According to research by Gary Stoner (Ohio State University), ellagic acid stimulates activities of enzymes that detoxify carcinogens.

RaspberryApoptosis is defined as “programmed cell death”. Preliminary researches are quite positive with even small concentrations inhibiting growth within 48 hours and causing apoptosis within 72 hours. Dr. Daniel Nixon  (Medical University of South Carolina) found that ingesting 40 mg of ellagic acid daily, (which is the amount of ellagic acid contained in 1 cup of red raspberries), can cause cancer cells to undergo apoptosis.

According to some research, ellagic acid reduces the effect of estrogen on cancer cell growth in breast tissue and promotes the breakdown and removal of cancer-causing substances in the blood via the liver. Ellagic acid may slow the growth of breast and cervical cancer, according to “Ohio State University” scientists. A new study in cell cultures found that ellagic acid may act against substances that help tumors to form new blood vessels. Ellagic acid prevents the destruction of P53 gene by cancer cells. Can bind with cancer causing molecules, therefore making them inactive. P53 gene, has the capability to rebuild damaged DNA under normal conditions. However, as part of cancer development it becomes switched off.

The ellagic acid found in raspberries, has been shown to help avoid overactivity of specific pro-inflammatory enzymes as well as their overproduction. “The Journal of Agricultural and Food Chemistry,” December 2011 has published the anti-inflammatory activities of polyphenolic-enriched raspberry extract in an antigen-induced arthritis in rate model. Anti inflammatory products like aspirin and ibuprofen, inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) resulting in the decrease of pain associated with arthritis, gout and other inflammatory conditions.  (The COX inhibitory activities of anthocyanins from raspberries were comparable to those of naproxen and  ibuprofen at 10 µM concentrations).

Raspberries, a rich source of anthocyanins and help in reducing the risk of cardiovascular diseases. Scientists proved that the antioxidant effect of anthocyanins from raspberries was superior to vitamin E at a test concentration of 125 µg/ml. Epidemiological studies suggest that increased consumption of anthocyanins lowers the risk of cardiovascular disease, the most common cause of mortality among human. Anthocyanins have demonstrated anti-oxidative and anti-inflammatory  properties, and a high intake of anthocyanin have indicated positive effects on blood pressure and other cardiovascular risk factors. In addition, raspberry is a source of salicylic acid, a compound similar to aspirin. Salicylic acid is found in raspberries and is suggest of having the same preventive activity against cardiovascular disease as aspirin. A 100-g serving of red raspberries includes around 5 mg of salicylic acid.

Raspberries include a especially winning combination of vitamins which act as against age-related eye diseases such as glaucoma and macular degeneration. According to an article published in “Archives of Ophthalmology”, a people who eats at least three servings of fruit per day has a reduce risk of macular degeneration than one who consumes half as much or less. Macular degeneration is an age related health problem which affects vision.

Mustard Benefits and Health

MustardMustard is a member of the Brassica family of plants. There are 3 main types used to make mustard seeds; white mustard (Brassica alba), brown mustard (Brassica juncea) and black mustard (Brassica nigra). Allyl isothiocyanate belongs to a family of naturally occurring isothiocyanates and is a promising cancer protective compound. Mustard seed powder is a well-known rich resource of allyl isothiocyanate with centuries-old history of use in Ayurvedic medicine and Chinese traditional medicine. In animal-based studies intake of isothiocyanates has been shown to inhibit growth of existing cancer cells and to be preventive against the formation of such cells.

Mustard Benefits

Mustard seeds are rich in nutrients such as glucosinolates and isothiocyanates. Isothiocyanates are biologically active hydrolysis products of glucosinolates. Isothiocyanates have been found to inhibit proliferation and induce apoptosis in a number of cancer cell lines. Naturally occurring isothiocyanates and their metabolites have been found to inhibit the occurrence of chemically-induced cancers of the liver, lung, stomach, esophagus, colon, and small intestine in a variety of animal models.

Scientists at the “Johns Hopkins University School of Medicine” in Baltimore explored the metabolism of isothiocyanates and showed that isothiocyanates were approximately 6 times more bioavailable than glucosinolates. According to a research reported in Carcinogenesis in May 2003, allyl isothiocyanate (AITC) is influential against prostate cancer cells. Allyl isothiocyanate is a promising agent for bladder cancer protection and therapy. A recent study shows that a plant compound -allyl isothiocyanate (AITC)- in mustard and horseradish may be effective in fighting bladder cancer. According to” Environmental Health News“, a study performed on rats that were given mustard seed powder found the plant compound  ‘stopped the growth of bladder cancer by one-third and completely prevented metastasis — the cancer invasion of surrounding muscle tissue.’

Banaba Benefits and Diabetes

Lagerstroemia speciosaBanaba (Lagerstroemia speciosa) is a species of Lagerstroemia native to tropical southern Asia. The tree is called the Crape Myrtle. The leaves of the Banaba and other sections are used often by the, Taiwan, and Philippines as a tea preparation. In isolated cells, corosolic acid, is known to stimulate glucose uptake. In vitro experiments show that banaba extracts demonstrated a similar activity to insulin in causing glucose update by cells. In addition, banaba leaf includes a elevated concentration of antioxidant compounds for protecting against oxidative stress and indicates anti inflammatory effect.

Banaba Benefits

Banaba have been used for long years in traditional medicine to treat diabetes, with the first published research study being reported in 1940. The banaba extracts include corosolic acid, a component being studied for its insulin like effect of lowering the glucose in the body. The active insulin-like triterpenoid component, corosolic acid, has been shown to stimulate glucose into cells andis effective in reducing blood glucose and insulin levels. (On the other hand, unlike insulin, banaba extract has been found to be effective when taken orally). Other important properties in banaba extract contain the phytochemicals lager-stroemin, flosin B and reginin A, which could also play a role in the blood glucose level reduction.

Researches performed by Dr. Yamazaki, have shown that the banaba includes corosolic acid, which has insulin-like effects. Studies performed by Dr. William V. Judy, confirmed that corosolic acid lowers the blood sugar levels. In a study reported in “Bioscience, Biotechnology, and Biochemistry” in 1996, researchers showed that treating diabetic mice with banaba extract (diet containing 5% of the hot-water extraction from banaba leaves) helped protect against high blood sugar levels. The antidiabetic effect of an extract from the leaves of banaba standardized to 1% corosolic acid (glucosol preparation) has been showed in a randomized study involving Type II diabetics. Glucosol at daily doses of 32 and 48 mg for two weeks demonstrated a important decrease in the blood glucose levels. Blood sugar levels, were 20 % less with powder capsules, and 30 % less with a softgel extract. (July 2003 edition the Journal of Ethnopharmacology).

Dosage

It is usually administered in daily doses of 8-48 milligrams, with a 1-2% concentration of corosolic acid. High doses should be avoided due to the likely for hypoglycemia.