Rooibos Benefits and Cancer

Rooibos (Aspalathus linearis) is a broom-like member of the legume family of plants growing in SouthAfrican fynbos. “Rooibos” means literally red bush in Afrikaans. Tea, is made from the fermented needle-shaped leaves of the rooibos shrub. Rooibos tea goes through a fermentation process. During the fermentation of the leaves, some chemicals are oxidized by enzymes resulting in the typical red colour of rooibos. Two polyphenol antioxidants known as nothofagin and aspalathin are found in high levels in rooibos tea. Aspalathin constitutes approximately 1.5 %of dry Rooibos leaves. The tea is completely free from caffeine content and is low in tannin. Tannin has been said to decrease the iron in tea drinkers by about one third.

Rooibos Benefits

The main flavonoids in rooibos are dihydrochalcone aspalathin, chrysoeriol, nothofagin, luteolin, orientin, vitexin, isovitexin, quercetin and rutin. Rooibos is the only known source of antioxidant called aspalathin. Nothofagin and aspalathin, have more strongly anti-oxidative effect than other flavonoids. Different researches have shown that rooibos tea contain potent free radical scavengers and help to protect cells and important cellular components such as lipids, proteins and genetic material against oxidative damage. Rooibos tea promote the production of antibodies that may be important in the therapy of cancer, AIDS and other different ailments, according to a  research reported in the October 2001 Bioscience, Biotechnology and Biochemistry.

Animal-based studies demonstrate it has strong antioxidant,immune-modulating and chemopreventive properties. Rooibos tea enhances the body’s ability to avoid the ailment by increasing detoxifying liver enzymes and arresting and slowing down, DNA mutation. The antioxidants in rooibos tea are strong enough to measurably elevate the antioxidant levels in blood. The effect peaks approximately 1 hour after drinking 500 ml tea. The study findings, reported in “Food Chemistry” in May 2010, demonstrated that 15 healthful adults given 500 ml of rooibos tea increased antioxidant capacity 6.6 %.  Professor Gelderblom of the “PROMEC Unit of the Medical Research Counci” in Cape Town is conducting research on this herb. Rooibos has great promise as a source of anti-oxidants which in rats can induce a 400 percent enhance in the GSH/GSSG ratio which is certainly necessary for optimum health. Research has found that rooibos tea raised the ratio of reduced glutathione to oxidised glutathione by 100 percent in humans who consumed 6 cups a day over a period of 3 months. In wholesome cells, over 90 percent of glutathione is found in the reduced form, and less than 10 percent is oxidised. An increased level of oxidised glutathione is an indicator that toxic substances are harming the cells. In addition, Japanese researchers have found that rooibos includes a mimic of the enzyme SOD (Super Oxide Dismutase), an antioxidant which attacks the free radicals and limits their damaging effects.

Aspalathus linearisIn a study, Heidelberg University researchers showed that rooibos has the ability to promote longevity in living organisms. Using roundworms as a model, they produced evidence that rooibos tea reduced oxidative damage in their cells. Researchers were able to show that aspalathin played a important role in their survival rate by targeting stress and ageing related genes.

In 2011, researchers performed a study to test the activities of rooibos tea on different biological markers considered to be indicative of risk for cardiovascular and other degenerative ailments. A high use of rooibos resulted in pronounced reductions in lipid peroxidation, low density lipoprotein (LDL) cholesterol, triglycerides, and an increase in high-density lipoprotein (HDL) cholesterol levels compared with the control group. A study performed in healthy people demonstrated that rooibos tea inhibits the ACE (angiotensin converting enzyme), which may have cardiovascular properties.  ACE is believed to be related in the development of cardiovascular disease, and thus angiotensin converting enzyme inhibitors are used to treat hypertension and heart illness. According to a article in the “Journal of Pharmacological Science“; chrysoeriol, can avoid and treat vascular disease by inhibiting the migration of smooth muscle cells inside the aorta, a important cause the narrowing or hardening of the arteries that may lead to a heart attack. A 2008 study performed by Dr. Jeanine Marnewick at the “Cape Peninsula University of Technology” (CPUT), demonstrated that 6 cups of Rooibos tea per day holds positive effects, and particularly helps to minimize oxidative stress in the body and lower the risk of heart disease.

An important study has been done with mice models proving the capability of Aspalathus linearis to delay the development of skin cancer lesions, decrease pre-cancerous lesions in the liver and inhibit the development of papillomas in the oesophagus. Topically applied this plant elicits a protective activity against microsomal lipid peroxidation and may help decrease chemical-induced tumor formation. In a 2009 study showed that topical application of polyphenol-rich extract of rooibos prior to UVB exposed skin inhibited the formation of tumours. Animal-based study reported in “Mutation Research” found that rooibos inhibited premalignant changes in the tissue-cultured mouse cells that were exposed to X-rays. The inhibiting action took place when cells were treated with as 2 % rooibos solution and peaked when cells were treated with 10 % solution. South African researchers from the Medical Research Council’s PROMEC Unit and the Oxidative Stress Research Centre at the Cape Peninsula University of Technology have found that rooibos could help avoid skin cancer. Dr Marnewick, who is a scientist in the MRC’s PROMEC research unit, obtained impressive findings with a skin cancer study. Dr Jeanine Marnewick and her team, investigated the effect of rooibos and honeybush extracts on UV-induced skin tumours in mice. The study found that green rooibos shrunk the dimension of the tumours by 91 percent and fermented rooibos by 97 percent. The finding for the green honeybush was 91 percent, and 95 percent for fermented honeybush. It found that unfermented rooibos decreased the number of tumours per mouse by 75 percent and fermented rooibos by 91 percent. The results for honeybush were 86 percent and 64 percent. Researchers concluded that polyphenol-rich extracts from rooibos have antitumour and photoprotective effects.

Dr Jeanine Marnewick says that rooibos tea protects against cancer in diverse ways. 1) Rooibos tea decreases cancer-associated changes in cells by protecting them against DNA damage or mutagenesis. 2) Rooibos may avoid a cell with damaged DNA from becoming a cancerous cell. 3) Rooibos tea may prevent cancerous cells from multiplying into masses and creating cancerous tumors. 4) Rooibos enhances the level of natural anti-oxidants in the liver, which means that the liver’s anti-oxidant status is developed. 5) Rooibos tea helps the liver to get rid of compounds that can cause cancer.

In a study, we analyzed the activity of Aspalathus linearis tea extract on antigen-specific antibody production and cytokine generation in vitro and in vivo. The results of suggested that rooibos extract may facilitate the antigen-specific antibody production through selective augmentation of IL-2 generation in vitro and in vivo.

The alkaline extract of rooibos leaves appear to suppress HIV-induced cytopathicity. Rooibos tea has been shown to have an favorable effect on the human immunodeficiency virus in 2 different study performed in Japan in 1997.  The researches focused on the effects of polysaccharides. These are substances found in rooibos tea that have effect in preventing the HIV from binding to T cells. The polysaccharide amalgams available in rooibos tea prevents the HIV from sticking to its intended or target cells in the body. Dutch scientists has showed, that Rooibos has strong antiviral effect against rotaviruses that cause serious infections. The researchers investigated 150 extracts with known to test its activity on rotaviruses. They found 11 extracts able to inhibit rotavirus, but just 3, including rooibos tea, were found to have powerful and important antiviral effect.

Scientists from “Stellenbosch University” have discovered that rooibos tea includes compounds that can help to reduce stress and anxiety. According to research, there are a number of compounds (aspalathin and nothofagin) present in rooibos tea that interfere with the production of the stress hormone called cortisol. Researchers found that rooibos tea alleviate the production of cortisol in the cells. The research results were reported in “The Journal of Steroid Biochemistry and Molecular Biology”.

Rooibos includes anti-spasmodic substances which can relieve stomach pains. Rooibos tea is useful in treating stomach cramps thanks to the calming effect of the flavonoids on the digestive system. The flavonoid chrysoeriol seems to be primary responsible for the  antispasmodic activity. Rooibos has been shown to inhibit in vitro activity of xanthine oxidase (XO). Xanthine oxidase plays a role in conversion of purine to uric acid in humans and reducing the effect of Xanthine oxidase could limit uric acid production, which would aid in therapy of gout.

Bloodroot Uses and Cancer

Bloodroot (Sanguinaria canadensis) is a perennial herb in the poppy family. Grows primarily in North America and in India. This herb produces blood-red sap from its fresh roots. The rhizomes include alkaloids, responsible for different pharmacological effects. The main bioactive components of bloodroot are alkaloids, mainly sanguinarine. Fresh bloodroot sap or an infusion of the root can be applied externally to treat eczema, warts, ringworm, ulcers, and benign skin tumors.

Bloodroot Uses

Sanguinaria canadensisBloodroot was included in the United States Pharmacopoeia from 1820 to 1926 as an botanical medication. The important component of bloodroot is sanguinarine, an alkaloid that indicates anticancer, antiangiogenic, anti-inflammatory, antimicrobial, anti-fungal, antimicrotubule and anesthetic effects. Sanguinaria canadensis used as an coughs, sore throats, antiseptic, emetic and cathartic to treat such conditions as skin cancer, inflammation and infection. It has also been used on warts, ringworm, nasal polyps, and periodontal infections, gingivitis, and plaque. Bloodroot (sanguinarine) exhibits antiplatelet activities and decreases platelet thromboxane production. Also, in a research reported in the Journal of Herbs, Spices and Medicinal Plants in 2009 bloodroot were found to modulate and stimulate human immune cells.

Researchers have isolated, sanguinarine, as the anti-cancer constituent. Sanguinarine, is also found in the greater celandine. In the 1800s, bloodroot was used as an ointment on breast tumors. Sanguinaria canadensis and zinc chloride  are two agents that are used as part of the Mohs chemosurgery fixed-tissue technique. When mixed with zinc oxide, blood root creates a corrosive paste that digests skin tissue. Allopathic use of bloodroot as an escharotic (Escharotic therapies are localized treatments utilizing herbs that are corrosive or caustic. Corrosive salves are usually referred to as ‘escharotics’ because they produce a thick, dry scab named an ‘eschar’ on the skin.)  for treating skin cancers was popularized by Frederick Mohs, who used a bloodroot paste to assist in the demarcation of the lesion, allowing a targeted surgical excision. It is a combined of blood root and zinc chloride and is known as “Mohs chemosurgery,” after F. Mohs, who invented the method. Scientists from University of Wisconsin have shown that bloodroot (sanguinarine) possesses powerful proapoptotic  and antiproliferative effects against human epidermoid carcinoma A431 cells, immortalized human HaCaT keratinocytes, androgen-unresponsive human prostate carcinoma DU145 cells and human prostate carcinoma LNCaP cells. Nevertheless; the effect of bloodroot needs more research before it is approved as a therapeutic cure for cancer.  (The FDA includes bloodroot on the list of  ‘Fake Cancer Cures‘ that consumers should avoid.)

Sanguinarine, has been used as a toothpaste for mouthrinse ingredient. Some studies have shown that mouthwash containing  zinc and sanguinarine is effective in reducing plaque formation. It acts as an antiseptic that avoids bacteria from forming plaque on teeth. A study reported in 2005 shown that a toothpaste containing sanguinarine and fluoride helped to avoid dental cavities better than just fluoride.  Small proportions of sanguinarine have been approved by the US Food and Drug Administration for use in toothpastes to help tussle gingivitis. In a announcement  from 2003, the FDA Dental Plaque Subcommittee of the Nonprescription Drugs Advisory Committee concluded “…that sanguinaria extract at 0.03-0.075% concentration is safe, but there are insufficient data available to permit final classification of its effectiveness in an oral rinse or dentifrice dosage form as an antigingivitis/antiplaque active ingredient.

Bloodroot Side Effects

Bloodroot should be used only under the supervision of a doctor. Are not recommended for glaucoma patients, pregnant women, breast-feeding women, and children. Adverse effects include nausea, vomiting, grogginess, burning feeling in the stomach and drowsiness. High doses can cause  blurring of vision, slowing of heart beat, shock, coma. Topical use of blood root for skin cancer can lead to negative effects including disfigurement. Use of blood root as an escharotic agent in the form of a paste or salve has led to localized tissue damage and disfiguring scarring in a number of case reports. No scientific studies have examined the efficacy of escharotic agents as therapies for cancers.  Goldman and McDaniel reported 4 case studies documenting treatment failures or complications with their use. In a study of bloodroot as adjunctive treatment for HIV, patients were unable to tolerate doses over 5 mg, due to vomiting and nausea, vertigo and and dizziness angioedema.

Gooseberry Benefits and Health Effects

Gooseberries are one of the 4 wild Ribes species growing in the Northern Hemisphere. The genus Ribes  includes white and red currants, black currants, and gooseberries. The European gooseberry (Ribes grossularia) is native to Caucausus Mountains and North Africa region, while the American gooseberry (Ribes hirtellum) is native to northeastern and north central United States and Canada. European gooseberries typical dimension is approximately 1 inch length. Colors consist of white, yellow, red as well as purple shades. The American gooseberry (Ribes hirtellum), a hybrid species, is 3 to 4 feet high. The tart, rounded berries are slightly smaller than cherries and may be red, green, purple, white, or yellow. Indian gooseberries (Phyllanthus emblica) known as amla in the subcontinent belongs to different family of Euphorbiaceae.

Gooseberry Benefits

Gooseberries (Ribes grossularia) are an important source of vitamin A, vitamin B, vitamin C, potassium, phosphorus and iron. Consumption of berries from  sources including the genus Ribes has been associated with positive health effects. Gooseberries are especially high in vitamin C and the group of antioxidants known as anthocyanins. Have been shown to help decrease the signs of aging, particularly with the high amounts of antioxidants in the darker red and purple varieties.

Vitamin C is critical for many basic processes in the body. Vitamin C is important for bones and connective tissues, Acerolamuscles, immune system and blood vessels. Vitamin C is a strong antioxidant. Antioxidants block some of the damage caused by free radicals, substances that damage DNA. Antioxidant properties of vitamin C have been demonstrated in many experiments in vitro. The role of vitamin C in the functioning of immune cells is well proven. Vitamin C has been shown to stimulate both the production and function of leukocytes, particularly neutrophils, lymphocytes and phagocytes.

Ribes grossulariaAnthocyanins may help prevent cardiovascular disorders, inflammatory responses, cancer, and degenerative diseases. Anthocyanins also improve neuronal and cognitive brain functions, ocular health as well as protect genomic DNA integrity. In recent years, numerous publications have demonstrated that besides their in vitro antioxidant capacity, certain phenolic compounds, such as anthocyanins,  proanthocyanidins, and other flavonoids, may regulate different signaling pathways involved in cell survival, growth and differentiation.

Other significant component of gooseberries is potassium. Potassium is an electrolyte that is necessary to electrical reaction in your body, including heart.  A diet too high in salt and too inadequate in potassium doubles the risk of death from heart disease, according to a “Center for Disease Control” study led by researcher Elena V. Kuklina. Patients hospitalized after a heart attack who had blood potassium rates of between 3.5 and less than 4.5 mEq/L had a lower risk of death than patients with potassium rates that were higher or lower than this range, according to a research in the January edition of “JAMA”.

Ribes grossularia are a important source of soluble fiber. A single serving of fresh gooseberries includes approximately 6.5g of soluble fiber. Fibers helps avoid constipation. Even more important, people with high intakes of dietary fiber appear to be at  reduce risk for developing diabetes, hypertension, stroke, coronary heart disease, and some gastrointestinal diseases. (The recommended dietary fiber intakes for children and adults are 14 g/1000 kcal. That means a person who eats 2,500 calories each day should get at least 35 grams of fiber daily).

Indian Gooseberries

Phyllanthus emblica  (Indian gooseberries) known as amla in the subcontinent belongs to different family of Euphorbiaceae. According to ayurvedic medicine, Emblica officinalis may be used as a rasayana to promote longevity, and has also been used to increase digestion, developed heart health, helps purify blood and stimulate hair growth.  The effects of Indian gooseberry is attributed to its antioxidant constituents, such as vitamin C, polyphenols, tannins and flavonoids. Includes high levels of Vitamin C Amla helps in increasing the number of red blood cells in body. Lab tests demonstrated that every 100 grams of fresh fruit provides 470 – 680 mg of vitamin C. Vitamin C is a strong antioxidant.

Alongside its strong antioxidant activity, the fruit of Amla has been reported to possess immunomodulatory, chemopreventive, antimutagenic, antiproliferative and effects that are useful in the prevention and therapy of cancer. Amla was shown to decrease inflammation in laboratory experiments. Some studies  found that 500 mg of Amla a day for three months lowered  CRP (C-reactive protein) levels. Indian gooseberry extracts are powerful antioxidants and help prevent lipid peroxidation, which is a key step in arterial hardening and cardiovascular illness.

The presence of chromium helps to control the blood sugar level which is quite important in type 2 Diabetes (non- insulin-dependent diabetes mellitus). Regular use of Indian gooseberry helps in the secretion of insulin by stimulating the cells and reduces the blood sugar levels in patients with diabetes. Indian gooseberry is a herb used  to alleviate gastric upset, including excess acidity in the stomach.queous and alcoholic extracts of Amla have shown protective and therapeutic activity in induced gastric ulcers in animal experiments.

Mucuna Benefits and Side Effects

Mucuna pruriens (cowhage), is a flowering vine in the legume family native to India. Its seeds include the alkaloids, mucunine, mucunadine, mucunadinine, and prurienidine, outside ß-sitosterol, lecithin, glutathione, gallic acid and vernolic acid. They posses a number of other bioactive substances, including tryptamine, steroids, alkylamines, cardenolides, coumarins and substances like zinc, iron magnesium and manganese.

Mucuna Benefits

This herb are used for the management of different free radical-mediated diseases, such as diabetes, male infertility, nervous disorders, atherosclerosis, and rheumatoid arthritis. Seeds of Cowhage possess  hypoglycemic, lipid lowering, antioxidant, and neuroprotective activities. There are findings that seed powder of Mucuna pruriens  helps in some way against stress, it enhances secretion of semen and it acts as a restorative and an invigorating tonic in diseases characterized by loss of sexual power. M. pruriens has  been used in Ayurvedic remedy for diseases including parkinsonism. The activity of Mucuna pruriens is due to the fact that these seeds contain 3-4% levodopa, the standard therapy for Parkinson’s disease. Also, the bioactive alkaloids in M. pruriens have been found to stimulate testosterone secretion and boost the sperm count of animals.

Parkinson’s Disease

The substantia nigra is a part of the brain that contains a important level of dopamine, a neurotransmitter involved in body movement and balance. In Parkinson’s disease, the substantia nigra degeneration and nerve cells die. M. pruriens has been found to include L-DOPA, 40 mg/g of the herb. The L-Dopa content enhances when extracts are prepared. L-Dopa is an amino acid that converts into dopamine. L-dopa is changed to the chemical dopamine in the brain. This chemical significantly affects dopamine metabolism in the striatonigral tract.

CowhageM. pruriens possesses significantly higher antiparkinson effect compared with levodopa (Levodopa is the standard administration used for therapy of parkinson’s symptoms) in the 6-hydroxydopamine lesioned rat model of Parkinson’s disease. Unlike synthetic levodopa therapy, M. pruriens cotyledon powder therapy significantly restored the endogenous levodopa, dopamine, serotonin and norepinephrine content in the substantia nigra. In an animal-based study reported in the September 2004 edition of the journal Phytotherapy Research, scientists, approved that administration of M. pruriens restored the levodopa, dopamine, serotonin and norepinephrine content in the brains of rats.

Some small-scale studies, M. pruriens  was found to decrease symptoms in patients with parkinson’s disease. In a study, 15-30 g daily (4.86% Levodopa; 500 -1000 milligrams daily), was equally effective as normal Levodopa (200mg/50mg) therapy in treating symptoms of parkinson’s disease. In another clinical trial, the bean powder was given to 60 patients. There were statistically noteworthy reductions of  symptoms in all study participants. A 2007 study by the “Department of Neurology at Scott  & White Clinic” evidenced, anti-parkinson M. pruriens prevents levodopa-induced plasmid and genomic DNA damage.

Growth Hormone

L- Dopa includes natural secretagogues which may enhance the body’s ability to stimulate the release of growth hormone. Taking M. pruriens extract in l-dopa stimulates the secretion of Hgh (growth hormone) by the pituitary gland. Growth hormone encourages muscle mass, improves stamina and energy levels, improves a sense of well-being and has a useful affect on many other conditions of health.

Libido and Infertile

Elevated levels of dopamine can result in a more effective libido. As well as, dopamine can trigger the pituitary gland, which regulates various of hormones into producing higher proportion of testosterone. In animal experiments, M. pruriens stimulates libido and sexual behavior, and increases performance, while elevating serum testosterone levels.

A 2007 clinical trial by the departments of biochemistry, at “King George’s Medical University”, found that M. pruriens, elevated spermatogenesis and improved sperm motility. The total alkaloidal extract from the seeds produced an boost in the numbers of spermatozoa and the weights of the testes, seminal vesicles and prostate of treated rats. Therapy with M. pruriens induces secretion of the male hormone testosterone, luteinizing hormone, adrenaline, noradrenaline and dopamine in infertile male. M. pruriens supplement in infertile men is associated with enhanced sperm count and motility after taking 5 g of dried powder for three months; in addition improves various parameters of male semen indicative of increased fertility. The scientists also looked at the concentration of adrenalin and noradrenalin in the men’s blood. Both increased, which is to be expected.

Hyperprolactinemia

Prolactin is a hormone released by the pituitary gland; high amounts are considered to reason erection insufficiency in males. M. pruriens has been shown to prevent prolactin levels in vivo, vicariously through dopamine effect to suppress prolactin secretion. There is some findings that mucuna pruriens might be beneficial for treating hyperprolactinemia in men caused by the drug chlorpromazine.  In approximately 10 to 40 percent cases of male infertility, excess prolactin secretion is responsible for low sperm production and poor libido. In a clinical trial, intake of the seeds in 56 male was able to develop erection and post-coital satisfaction after just 4 weeks of therapy.

Blood Sugar Levels

This herb may be found beneficial in treating patients suffering from diabetes. An ethanol-water extract of the seed, root, and  fruit decreased blood sugar levels in rats by more than 30 percent.200 mg an ethanol extract provided a 40 percent decrease in blood glucose within 1 month, and a 51 percent decrease at 4 months.

Anti-Venom Agent

M. pruriens has been used as an anti-venom agent, particularly against the venom of a Echis carinatus (a snake).  This venom affects the coagulative cascade, causing severe bleeding and haemorrhage. Researches on its effects against Echis carinatus, Bangarus, and Calloselasma have shown it has possible use in the prophylactic therapy of snakebites.

Mucuna Pruriens Side Effects

M. pruriens should not be used during pregnancy. The seed may cause birth defects. Mucuna may interact with some drugs. M. pruriens is contraindicated in combination with Monoamine Oxidase Inhibitors (MAOIs). Parkinson’s disease patients  taking levodopa, dopamine antagonists or dopamine agonists should consult their doctor before taking the supplementation to prevent toxic psychosis. According to a article reported in “Lancet“, M. pruriens seed extract may cause toxic psychosis in schizophrenia patients.

Carnosine Benefits and Dosage

Carnosine (ß-alanyl-L-histidine) is a protein molecule made up of two amino acids, histidine and beta alanine. Classified as a dipeptide. Carnosine is substantial for many normal body functions including improvement of the muscles, liver, heart, brain, kidneys, and other organs. The muscles contain about 20 µmol/g dry weight. This chemical compound were discovered by Russian chemist V. Gulevich. L-carnosine is naturally occurring in all of our bodies; however, it depletes with age by approximately 10 % per year, after we reach the age of 30.

Carnosine Best Food Sources

Meat is the basic dietary source of carnosine. Other dietary sources of carnosine include, milk, eggs, cheese, fish, poultry and pork products. Absorption of carnosine from food is 30 to 70 % and that of pure L-carnosine greater than 70 percent.

Carnosine Benefits

In lab and animal experiments, researchers have found that carnosine may offer various a positive effects, such as inhibiting the buildup of amyloid beta, preventing diabetes-related nerve damage, and promoting vasodilation.

Antioxidant

CarnosineL-carnosine is an antioxidant which stabilizes and protects the cell membrane. Found in elevated concentrations in muscles and brain tissue, carnosine is backed by studies to support its capability to scavenge reactive oxygen species, which can lead to free radical damage. Carnosine has been shown to scavenge reactive oxygen species, as well as alpha-beta unsaturated aldehydes formed from peroxidation of cell membrane fatty acids during oxidative stress.

L-carnosine functions as a broad-spectrum antioxidant and supports the wholesome functioning of enzyme systems. In addition, carnosine is capable of inhibiting cell membrane oxidation due to the action of copper, zinc, iron, hydrogen peroxide, the oxygen radical, and the free peroxide and hydroxylic radicals. As an anti-inflammatory and antioxidant agent, carnosine supports DNA synthesis and stops its destruction, which can be the reason of cancer. In a study, mice were injected with solutions of carnosine at various doses for 5 consecutive days. On the fifth day mice were injected with the chemotherapy medication, cyclophosphamide. Bone marrow and blood cells were then analyzed. L-carnosine significantly decreased both damage to bone marrow and blood cells toxicity normally induced by chemotherapy drug. (Cell Biochemistry and Function).

Anti-Aging

L-carnosine is a chemical compound that protects and extends the functional life of the body’s key building blocks-cells, proteins, DNA, and lipids and can be quite called an agent of longevity. In a study conducted; found that adding carnosine to the diet of fruit flies produced a 20 percent increase in the average life span of male flies. (Rejuvenation Research 2010). A experiment on mice later demonstrated that mice given carnosine are  twice as likely to reach their maximum lifespan as untreated mice. 44 percent of the carnosine treated mice had young, glossy coats in old age as opposed to just 5 percent in the untreated mice. Just 9 percent of the untreated mice behave youthfully in old age, versus 58 percent of the carnosine treated mice. The scientists additionally measured biochemical indicators associated with brain aging. Carnosine treated mice had important reduce levels of toxic malondialdehyde in their brain cell membranes. Monoamine oxidase B (MAO-B) activity was 44 percent reduce in the carnosine treated mice, indicating maintenance of youthful dopamine metabolism.

Telomere

A telomere is a region of repetitive nucleotide sequences at each end of a chromatid, which protects the end of the chromosome from deterioration or from fusion with neighboring chromosomes. Telomere regions deter the degradation of genes near the ends of chromosomes by allowing chromosome ends to shorten, which necessarily occurs during chromosome replication. Over time, due to each cell division, the telomere ends become shorter. Telomere shortening is intimately involved in human ailment and mortality. Several studies  have shown associations between shorter telomere length and various types of cardiovascular illness and diabetes. Shorter telomeres have also been associated with dementia, cognitive function, cancer, arthritis, and osteoporosis.

Due to the powerful antioxidant effect of L-carnosine, is shown to play a preventive role in  preventing telomere damage while decreasing the rate of telomere shortening during cell division, slowing down the aging process. L-carnosine, has been reported to delay the replicative senescence, and extend the lifespan of cultured human diploid fibroblasts. Telomere shortening is induced by oxidative changes and other protein modifications of precisely the kind that carnosine can prevent. Carnosine can thus block telomere shortening and decrease aging effects in individual tissues. Scientists reported in the journal “Arteriosclerosis, Thrombosis, and Vascular Biology” have found that telomere shortening accurately predicts the probability of developing heart illness, a heart attack and early death from all causes.

Anti-Glycation Effect

New researches suggests that the most substantial action of carnosine is its anti-glycation impact. Glycation is a process that involves the denaturation of proteins. It is acceptable to be a important factor in accelerating the whole ageing process, at a physical and cellular level. Glycation can be called as the binding of a protein molecule to a glucose molecule resulting in the formation of damaged, nonfunctioning structures. Glycation alters protein structure and reduces biological activity. Glycated proteins, which accumulate in affected tissue. Several  age-related ailments such as cataract, arterial stiffening and neurological disorder are  partially attributable to glycation. Because of its anti-glycation properties, carnosine may be beneficial in preventing and treating diabetic complications such as neuropathy, cataract, kidney failure and arteriosclerosis. As part of its anti-glycation function, L-carnosine reacts with aldehydes and ketones which accumulate on proteins during aging. Carnosine is an important antioxidant in defense against MDA (malondialdehyde). Malondialdehyde causes protein cross-linking and formation of advanced glycation end products. L-carnosine has been shown to avoid malondialdehyde from inducing protein cross-linking.

High Blood Sugar Levels

Carnosine reduces high blood sugar levels, develops insulin production and sensitivity, and promotes the loss of body fat. L-carnosine is considered to be a substance that, via the H3-receptors in the autonomous nerveous system, controls the levels of blood sugar. An animal-based study demonstrated that carnosine reduces blood glucose levels indirectly through positive effectiveness on the autonomic nervous system. A study reported in the July 1998 edition of Biochemical and Biophysical Research Communications found that carnosine may be beneficial due to its capability to inhibit the  processes that lead to the formation of advanced glycation endproducts which are indicated as the reason of secondary diabetic complications.

Eye Health

Carnosine containing eyedrops have showed effectiveness in treating a different of ophthalmic problems, including corneal diseases, increased intraocular pressure, glaucoma and cataracts, and impaired vision from any cause. Explained that researches out of Italy and Russia has shown that, l-carnosine, may be all that’s needed to dissolve cataracts, improve vision, and prevent redundant surgery. A new treatment for cataracts is NAC (N-acetylcarnosine). This therapy was improved by opthalmologist Dr. Babizhayev in Moscow. Many of the researches demonstrating the effectiveness of carnosine in preventing or treating cataracts in humans has been done by Dr. Babizhayev. Application of a 1 percent solution of N-acetylcarnosine to the eyes has dissolved cataracts. This works by preventing and reversing cross linking of the lens proteins that produces opacification and impaired vision. In 6 months, 90 percent of participants had developed vision. In 1994, scientists from the “Moscow Helmholtz Research Institute of Eye Diseases” linked the antioxidant effects of this compound to the possible for prevention or partially reversing cataract development. Researchers in China explained that carnosine-containing eyedrops used to treat 96 cataract patients over 60 years of age resulted in 100 % healing in primary senile cataract, and 80 %in those with mature senile cataract.

Cardiovascular

Some researches have identified the preventive effects of carnosine as being a powerful neutralising antioxidant in the presence of cardiovascular toxins thereby protecting against atherosclerosis and arterial plaque formation, a risk for or stroke or heart attack. According to new research, carnosine develops myocardial contractility during hypoxia as well as verapamil, a calcium channel blocker ofttimes prescribed for the therapy of heart illness and therefore carnosine opens new interests in therapy of myocardial insufficiency. Also, carnosine reduces platelet aggregation in people with abnormal clotting tendencies and enhances platelet aggregation in patients with low clotting indices.

Stroke

Researchers reported in the Cellular Physiology and Biochemistry showed that carnosine from supplement can help protect against a first stroke, and can significantly reduce the harm caused by stroke. Animal-based studies show that supplement with carnosine protects the brain cells against ischaemia which occurs during and after stroke. L-carnosine has beforehand been shown to provide protection against ischemia in cultured cells and global ischemia in rats. In animal-based study, experimental ischemic injury resulted in 67 percent mortality of the rats. In the group of animals pre-treated with carnosine the mortality was just 30 percent.

Brain Health

L-carnosine works as a neurotransmitter, an anticonvulsant and a chelator. Antioxidant effect, which has been examined with in-vitro and in-vivo models, has been shown to protect against the damage caused to neurons by free radicals, particularly the hydroxyl type. In chronic brain problems, Parkinson’s and Alzheimer’s  diseases, schizophrenia and, epilepsy, oxidation stress prevails and, also, all the other harmful interrelated reactions occur at a elevated rate. Various lab experiments, have reported high levels of metal ions such as copper, zinc in Alzheimer’s brain. Carnosine has the strong capability to chelate  zinc, copper, and other metals, and to remove them from the body.

Autistic Spectrum Disorders

There is some findings that l-carnosine supplements may be useful for children with autistic spectrum disorders.  In a double-blind, placebo-controlled study, 31 children with autism were given or carnosine (400 mg twice daily dose) or placebo for a period of eight weeks. After 8 weeks, children on carnosine demonstrated statistically important developments on the Gilliam Autism Rating Scale and the Receptive One-Word Picture Vocabulary test, and developed trends on the other measures used. (Journal of Child Neurology November 2002). Although the mechanism of L-carnosine effect in autism is not well understood, a possible conjecture is that it modulates neurotransmission in frontal lobe function.

Carnosine Dosage

The recommended daily dose is 50-200 mg. In his book (Carnosine and Other Elixirs of Youth), Dr. Marios Kyriazis reported that Russian doctors use 1000 to 3000 mg per day to treat cancer patients.