Stinging nettle has been used for hundreds of years to treat painful muscles and joints and arthritis. Researches have shown that the extract of the nettle leaf suppresses cytokines associated with inflammatory joint illness.

Stinging Nettle Benefits For Arthritis

In several studies nettle extracts were documented with anti-inflammatory effects as well as to be helpful at relieving arthritis pain and inflammation in humans. Studies conducted in Germany have showed scientifically that nettle is capable of inhibiting the genetic transcription factor that activates TNF-a and IL-1B. An ethanolic extract was found to suppress HLE (human leukocyte elastase). Human leukocyte elastase is one of the most destructive enzymes released by polymorphonuclear granulocytes, which migrate into tissues during the inflammatory process. Nettle extract in capsule form is prescribed in Germany for the pain of rheumatoid arthritis and osteoarthritis. Two clinical studies (Chubasik et al 1997) produced promising results of improvement in pain at rest (55%), pain on exercise (45%), physical impairment (38%) and reduction in consumption of non-steroidal anti-inflammatories in 60% of patients.

In a study reported in the Journal of the Royal Society of Medicine in June 2000 issue that nettle leaf can decrease osteoarthritic pain in the base of the thumb when applied to the painful area. Using nettles may decrease the need for NSAID (Nonsteroidal Antiinflammatory Drug). In a clinical trial of 37 people with acute arthritis, 50 g of stewed nettle leaf consumed on a daily combined with 50 mg of diclofenac was shown to be as effective as the full 200 mg dose of diclofenac in the therapy of symptoms, over a two week period. In a study reported in the Dec 2009 issue of “Arthritis Research and Therapy“, found that a combination of nettles, fish oil and vitamin E reduction the need for analgesics and other drugs to decrease the symptoms of osteoarthritis.

The tiny stingers of the nettle plant provide microinjections of several chemicals responsible for the stinging sensation the plant causes. The needles pump a mixture of formic acid, histamine, serotonin (5-hydroxytryptamine), acetylcholine, moroidin and leukotrienes into the epidermis, producing a stinging or burning sensation. These chemicals are anti-inflammatory and pain reducing. These neuro-transmitters send and receive signals to the brain and act on nerve endings to block the transmission and perception of pain. The benefits of nettle as a possible local painkiller were studied in 27 participants with osteoarthritis-related pain at the base of their thumb. Participants applied nettle leaf (Urtica dioica) daily for one week to the painful area. The effect of this therapy was compared with that of placebo, Lamium album  (white deadnettle leaf), for one week after a 5-week washout period. After one week’s therapy with nettle sting, score reductions on both visual analogue scale and health assessment questionnaire were significantly greater than with placebo.

Stinging nettle leaf extracts lessen inflammation, in part, by suppressing the release of inflammatory cytokines. They do this by blocking a chemical inducer known as NF-KappaB, which alters gene expresion. This may be one explanation for the favorable effects has exhibited in rheumatoid arthritis. The Journal of Rheumatology reported Dec 1999 the findings of a study by S. Klingelhoefer et al on the antirheumatic effect of IDS 23, (a nettle leaf extract), on in vitro expression of T helper cytokines. They concluded “may inhibit the inflammatory cascade in autoimmune diseases like rheumatoid arthritis.”  The nettle leaf extract IDS 30 has been recommended for adjuvant treatment of rheumatic diseases. April 2002, published a report about a study of the immmunosuppressant activity of IDS 30, on myeloid dendritic cells in vitro. The nettle extract IDS 30 has prevented the maturation of dendritic cells leading to reduced induction of primary T cell responses. Dendretic cells play an important role in the initiation of rheumatoid arthritis. Nettle extract was able to keep dendretic cells from growing, however did not kill the cells.

Spirulina (also called blue-algae) may boost your immune system by increasing antibody production in response to pathogens. These algae was found to increase immune response through enhanced production of the immunoglobulin IgA, interleukin-6 and interferon-gamma. Also, enhances immunity through increased phagocytic activity of macrophages, stimulates production of antibodies and cytokines, increases accumulation of natural killer cells in tissue, and activates and mobilizes T and B cells.

Spirulina Benefits and Immune System

Spirulina activates very of the several immune cells, including macrophages, T-cells, B-cells, and natural killer cells. Besides, activates the organs involved with immune function such as the spleen, liver, bone marrow, and thymus gland. In vitro experiments found that spirulina had antiviral activity against cytomegalovirus, mumps, measles, influenza A viruses, HIV and herpes simplex. Researchers discovered that it not just stimulates the immune system, also, improves the body’s ability to generate new blood cells.

In 1979, Russian researchers reported first research on the immune stimulating effects on rabbits from lipopolysaccharides in spirulina. More new researches in Japan and China have shown polysaccharide extracts increased macrophage function, antibody production and infection-fighting T-cells. Natural killer cells target and kill cancer in the body as well as enhance the ability to fight off disease. Some clinical trials have shown that spirulina may help the immune system fight off cancer cells by increasing NK (natural killer) cells. Two preliminary studies using spirulina at 400mg daily noted that natural killer cell activity increased by 40% and mRNA production of natural killer cells increased by 37-55% after a week of supplementation. Spirulina significantly increases cytokine production in cultured immune system cells, according to a research reported in the Fall edition of the “Journal of Medicinal Food“. According to a study reported in October 2005 in the Current Pharmaceutical Biotechnology; spirulina develops the activity of white blood cells, stimulates antibodies and enhances the number of natural killer cells.

At the 30th Annual Meeting of the Japanese Society for Immunology held in Nov, 2000, researchers from the “Osaka Institute” reported a spirulina clinical study. In the study, spirulina significantly increased the tumor-killing ability of natural killer cells and interferon-gamma in participants aged 40 and above, and it continued for  12 to 24 weeks after stopping the administration of spirulina. A new twelve-week study involving 30 participants over 50 who took Hawaiian Spirulina Pacifica, produced by Cyanotech, found improved immune blood markers in the majority of participants. The study found a steady improve in haemoglobin in both sexes with women benefiting more rapidly. Furthermore, found improved immune blood markers in the majority of participants.

The radioprotective properties of an extract of  Spirulina platensis has been investigated using the micronucleus test in polychromatic erythrocytes of bone marrow of mice. In this system the extract caused a important decreased of the micronucleus frequencies induced by gamma-radiation. Spirulina has a dark blue-green color, because it is rich in a brilliant blue polypeptide called phycocyanin, which affects the stem cells found in bone marrow. Researches show that phycocyanin affects the stem cells found in bone marrow. Phycocyanin also stimulate hematopoiesis, simulating the effect of the hormone erythropoietin. Hormone erythropoietin. is produced by healthy kidneys and regulates bone marrow stem cell production of red blood cells. Phycocyanin  regulates production of white blood cells, even when bone marrow stem cells are damaged by toxic chemicals or radiation. Based on this property, spirulina is approved in Russia for treating radiation sickness. This nutrient was shown to correct the immune cell parameters in a study with children exposed to prolonged low dose radiation in Chernobyl. In all the children an improve in T-lymphocytes and T-helper cells was seen, and T-suppressor cells were normalized. IgA levels became normal. In an animal-based study, spirulina was shown to modulate radiation induced hematological and biochemical alterations. Swiss Albino mice were exposed to gamma radiation. The average hemoglobin, total erythrocyte count and total leucocyte count were elevated in the group receiving spirulina.

Spirulina Against HIV

Compounds isolated from spirulina inhibit the replication of HIV in test-tube studies. A study reported in the Journal of Acquired Immune Deficiency Syndrome found that the use of spirulina inhibited HIV replication in the blood. Taking extract concentrations between 0.3 and 1.2 micrograms per milliliter reduced viral production by approximately 50 %. In 1989, the results of a study in vitro, demonstrated that sulfoglycolipids in blue-green algae (like spirulina) exhibited powerful antiviral activities. Other study, reported in the “Journal of Natural Products“, demonstrated that Ca-SP (Calcium Spirulan), a spirulina polysaccharide extract, too has antiviral effects. Recent studies indicate that spirulina also presents clinically important anti-viral and immuno-stimulating effects in people infected by HIV. A study conducted in Cameroon and reported on the May 2011 in “Nutrition and Metabolic Insights” showed the nutritional efficiency of spirulina in terms of weight gain in HIV-infected malnourished patients.

Spirulina is a type of blue-green algae. These algae produces body chemicals that attack tumor cells that cause cancer. Test tube and animal-based studies indicate spirulina may boost the immune system and anticancer effects.

Spirulina Cancer Benefits

Spirulina strengthens the immune system to fight against the formation of malignant tumors. In a 2002 Japanese study, twelve male participants were administered an oral hot water extract of spirulina, and the number and activity of their natural killer cells was measured before and after therapy. At the end of the study period, there was a significant increase in the production and cancer-killing ability of these participants’ natural killer cells. A study performed by a Chinese scientists reported in Biomedicine and Pharmacotherapy in Oct 2009, show that a combination of selenium and Spirulina plantesis may have the effect to avoid human breast cancer. A 2002 study by the Department of Animal Sciences at India’s University of Hyderabad from the US National Institutes of Health’s research data publication site, explains the process by which spirulina is able to inhibit the elevated levels of Cycloxygenase-2 associated with inflammation and cancer.

In mice with chemically induced stomach cancer, the tumor burden was reduced to half that of the control animals using high-dose spirulina therapy. Experimental studies in animal models have showed an inhibitory activity of spirulina on oral carcinogenesis. Preliminary study findings show that taking 1 g of spirulina fusiformis daily by mouth for 12 months reduces oral leukoplakia (a non-cancerous, but high risk pre-cancerous condition) in individuals who chew tobacco. According to a 1995 study published in “Nutrition and Cancer“, 45% of Indian patients who chewed tobacco reported a complete regression of pre-cancerous mouth lesions after receiving extracts of spirulina for 12 months. Spirulina has chemo-protective and radio-protective effect, and may be a potential adjunct to cancer treatment. Researchers in China have shown that spirulina increased the level of white cells in the blood and of nucleated cells and DNA in the bone marrow of mice that had been subjected to radiation and chemotherapy.

C-PC (C-phycocyanin) from Spirulina has been previously shown to have anti-cancer effects. It is a water soluble, non-toxic fluorescent protein pigment with strong antioxidant, anti inflammatory and anticancer activities. In a study the effect of highly purified C-Phycocyanin was investigated on growth and multiplication of human chronic myeloid leukemia cell line. The results demonstrate important reduction (49%) in the proliferation of K562 cells treated with 50 microM C-Phycocyanin  up to 48 hour. Researchers at the “Osaka Institute of Public Health” have found that spirulina extrac promoted the activation of natural cancer-fighting substances in the body. In this study participants over 40 years of age were given 50 ml of a spirulina extract (Lina Green 21) and the level of natural cancer-fighting substances were measured in their blood. The findings demonstrated that spirulina extract significantly increased the tumor killing ability of  NK (natural killer) cells and interferon gamma. The interferon gamma and NK cell activity was increased 1-2 weeks after administration of spirulina and the activity continued for 12-24 weeks  after stopping the administration of spirulina.

Spirulina has a dark blue-green color, because it is rich in a brilliant blue polypeptide called phycocyanin, which affects the stem cells found in bone marrow. Phycocyanin builds blood. Chinese researchers documented phycocyanin as stimulating hematopoiesis, emulating the affect of the hormone erythropoetin (EPO). Chinese researchers claim phycocyanin also regulates production of white blood cells, even when toxic chemicals or radiation damages bone marrow stem cells. Based on this property, spirulina is approved in Russia for treating radiation sickness. These algae was  used to treat children suffering radiation sickness after the Chernobyl disaster. Their bone  marrow is damaged, rendering them immunodeficient and unable to produce normal red or white blood cells. Children fed only 5 g of Spirulina tablets each day make impressive recoveries within 6 weeks. Children not given spirulina remain diseased. Research continuing through 1999 in Belarus demonstrated immune building, normalization of peroxide lipid oxidation and detoxifying effects of spirulina extract in children and teenagers.